乐动体育LDsports中国

早期检测仍然是增加卵巢癌妇女生存的最大机会之一。

我们假设称为Magsense™技术称为Magsense™技术的新型纳米磁性弛豫技术通过提供替代经管超声（TVU）作为癌症抗原125水平的患者的第二线诊断工具来实现这项任务（CA125）。Magsense仪器，想象Biosystems，Inc。，San Diego，CA，使用阵列超敏超导量子干扰装置（鱿鱼）来检测肿瘤结合的超顺磁性纳米颗粒（NPS）。通过注入生物靶向的NPS，施加短暂磁脉冲，然后用鱿鱼传感器检测所得信号来实现肿瘤检测。

Magsense技术是一种磁检测技术，依赖于与特定专有的超顺磁性纳米颗粒连接的靶向剂（抗体）的使用（PrecisionMRX®;想象中的Biosystems，Inc.，San Diego，CA）。将靶向的NPS注入细胞培养物或小鼠模型中，然后在场关闭之前施加小磁化场（50高斯）0.75秒。短暂磁场的应用允许使用鱿鱼传感器测量的待测生物标志物的细胞NPS，该传感器用于检测低磁场。鱿鱼传感器检测到绑定的NPS，因为一旦磁场关闭，棕色运动在小于1毫秒内的未结合NPS衰减，而Biomarker结合的NPS衰减以较慢的速率（0.1到2秒）Néel机制。然后使用鱿鱼传感器检测的信号来确定所结合的NPS所在的位置。

Unlike current second-line ovarian cancer screening methods (e.g., TVU), which are imaging-based and rely on visualization of the shape and other physical properties of the tumor, MagSense is similar to a blood test in that it detects the presence of cancer cells (along with their approximate location) using targeted NPs. The advantage of this technology is that it is up to 200 times more sensitive than current imaging technologies (based on unpublished data). In addition to the sensitivity advantages, it is also believed to be unparalleled in terms of specificity. Because the technology relies on NPs binding to specific cancer cells and is detecting molecular markers, only cancer will presumably be detected with this technology. Another advantage of MagSense technology, compared to some imaging-based technologies, is that it does not expose patients to potentially harmful ionizing radiation and, because this technology is considered to be safe for human use, we expect that human studies could begin within the next five years. Thus, MagSense technology holds promise for detecting ovarian cancer much earlier, which is crucial to increasing survivorship.

初步结果表明了体外Magsense技术的检测限（通过细胞滴定研究确定）是104卵巢癌细胞的顺序。此外，磁悬信技术已经能够成功地检测卵巢肿瘤体内。