洛佩兹-Berestein实验室

癌症纳米医学和生物学实验室

目前的研究乐动体育LDsports中国

我们的实验室探索癌细胞存活，肿瘤发生和肿瘤进展的机制和集中在识别信号传导途径调节增殖，侵袭，抗药性，细胞凋亡和自噬。这些研究提供了使用RNA干扰（siRNA和微小RNA），寡核苷酸，（反义），化疗剂和在癌症的小分子和各种其他疾病的治疗应用的发展理性和基础。纳米功能将通过使纳米颗粒利用能够提供治疗有效载荷发病部位和定位标识的分子途径是高度有效的靶向治疗的发展连接基础科学发现和临床应用的关键桥梁。

药物传递系统

In addition to our focus on understanding complex biological networks and identifying novel molecular targets in various solid and hematological cancers, we develop novel drug-delivery systems including lipid-based ( ie, nanoliposomes), polymer-based particles (i.e, chitosan, PLA) for delivery therapeutic agents to various solid tumors and hematological cancers . These nanocarriers are designed for the delivery of therapeutic agents to the tumor cells and microenvironment to maximize the therapeutic efficacy of anticancer agents and reduce their side effects if there is any. However, on the developmental component we will further develop a dual assembly nano particle that is capable of sustained release of ncRNAs as we’ll as it is easy amenable to targeting moiety assembly.

我们的长期目标是发展临床相关的，无毒，肿瘤可用于翻译成诊所，以改善患者治疗的治疗方案，进一步增强现有药物疗效目标的纳米治疗剂。