Amit Laboratory
莫兰·阿米特，M.D.，Ph.D.
主要调查员
Areas of Research
- 神经调节癌症研究乐动体育LDsports中国
- 肿瘤微环境研究乐动体育LDsports中国
- Head and Neck Cancer Research
欢迎来到阿米特实验室。我们是一个neuroscience and cancer biology research lab. Our goal is to advance the current understanding of the nervous system’s contribution to cancer. We have established experimental models in neuroscience research to uncover novel mechanisms used by the nervous system to promote tumor initiation, progression, and metastasis. We apply these tools to study complex biological processes that occur in human cancers including transformation, invasion, metastasis and chemoresistance evolution.
Scroll Ahead
Meet the Principal Investigator
莫兰·阿米特，M.D.，Ph.D.
主要调查员
Amit博士的目标是通知癌症研究的关键领域，包括预防和治疗实体肿瘤。乐动体育LDsports中国他的研究乐动体育LDsports中国侧重于神经系统促进肿瘤发育，进展和转移的机制。
Dr. Amit holds a clinical background as a head and neck surgeon trained in the department of Head and Neck Surgery, and he obtained a Ph.D. in Cancer Biology at the Israel Institute of Technology in Haifa, Israel.
He was recruited by the Department of Head and Neck Surgery to establish a Neural Regulation of Cancer section in a research program dedicated to studying the tumor microenvironment. He has developed novel modeling systems of the neural niche in the tumor microenvironment both in vitro and in vivo using syngeneic mouse models and imaging systems. He also has significant prior publications defining the role of immune cells in cancer dissemination along nerves.
Amit博士的长期目标是揭示支持肿瘤生长的微环境驱动的机制，并制定靶向这些途径的措施。
乐动体育LDsports中国研究焦点
我们的研乐动体育LDsports中国究重点在实验性癌细胞生物学和使用计算生物学方法研究肿瘤微环境亚步骤之间的均匀分开。我们开发了新的实验方法，以分离和序列神经利基群体，并应用分析方法研究实体肿瘤如何塑造它们的微环境。我们主要专注于头部和颈部癌，了解外周神经系统在侵袭，转移和化疗反应中的作用。我们的目标是了解神经信号传导在肿瘤演变中的作用，以便我们可以利用这些信号进行治疗漏洞和增强癌症治疗。我们充分预计将这些工具应用于患者将最终通知癌症研究的关键领域，包括预防和治疗头颈癌症。乐动体育LDsports中国
AMIT实验室特征
Dr. Moran Amit and his colleagues show that head and neck cancer cells can manipulate nearby nerve cells into promoting tumor growth. The researchers find that the cancer cells secrete vesicles containing small RNA molecules (microRNAs) that are taken up by nearby sensory nerve cells. If the cancer cells have a mutant form of the p53 protein, then the vesicles secreted do not feature a microRNA that blocks neuronal growth. As a result, the vesicles promote the proliferation of nerve cells and reprogram them to be adrenergic neurons, which aids tumor growth.
生活在实验室里
