在氧气缺乏的条件下经常遇到的肿瘤,癌症促进表皮生长因子受体(EGFR)牙龈了细胞的肿瘤抑制微RNA(miRNA) - 处理机械,由MD安德森的科学家领导的一个国际研究小组发现了。
“当缺氧强调细胞,EGFR信号防止不成熟的成长来对抗癌症的miRNA,”资深作者洪明奇博士,教授和主席分子与细胞肿瘤和露丝Legett琼斯的持有者特聘讲座。
该小组的研究结果指出了一个潜在的新的预后标志乳腺癌红注释,并且还提供一个生长因子信号传导途径调节的miRNA成熟的第一个证据。
This research was funded by grants from the U.S. National Institutes of Health, MD Anderson’s Cancer Center Support Grant from the National Cancer Institute, the U.S. National Breast Cancer Foundation, MD Anderson’s Center for Biological Pathways, Susan G. Komen for the Cure, the Sister Institution Fund of China Medical University and Hospital and MD Anderson, the Taiwan Cancer Research Center of Excellence, a Private University grant from Taiwan and the Taiwan Program for Stem Cell and Regenerative Medicine Frontier Research.