苏珊·史密斯(Susan Smith)没花多少时间就找到了一家可以纪念因多发性骨髓瘤而失去生命的姐姐琳达·查普曼·戈尔登(Linda Chapman Golden)的机构。
作为一名研乐动体育LDsports中国究数据协调员和病人一起工作临床试验在MD安德森在过去的十多年里,史密斯见证了慈善事业如何帮助医生拯救生命。她会见了罗伯特•Orlowski医学博士主席淋巴瘤或骨髓瘤,来讨论骨髓瘤患者如何从她姐姐的记忆中受益。
Orlowski的父亲,玛丽安Orlowski,医学博士,被提名为2004年诺贝尔奖研究蛋白酶体活动,告诉史密斯在他的实验室里的一些研究。一个重点领域,引起了她的兴趣是癌症发展的临乐动体育LDsports中国床前模型来理解常见的肿瘤基因异常。Orlowski解释说,通过对患者样本的基因分析,研究人员了解了骨髓瘤的许多亚型,这使医生能够尽快决定谁得到什么治疗。乐动体育LDsports中国然而,收集、处理、储存和分析这些病人的肿瘤样本可能非常昂贵,他补充道。
史密斯还了解到,当Orlowski在约翰霍普金斯医学院做博士后时,他发现与蛋白酶体抑制剂接触的细胞死亡得更快。有了这些知识,他为第一种针对蛋白酶体的药物硼替佐米(bortezomib)奠定了基础。现在,硼替佐米被用于治疗数以万计的患者多发性骨髓瘤。
奥洛斯基说:“把我父亲的研究从实验室推广到病人身上,真是令人兴奋。”乐动体育LDsports中国“我以他毕生的工作为基础感到自豪。”
Orlowski寻找持久疗法的决心激励了Smith通过她的家庭的Jake and Nina Kamin基金会帮助建立了Jake and Nina Kamin基金会,用于研究Linda Chapman Golden的多发性骨髓瘤。乐动体育LDsports中国
“多年来,我见证了临床试验是如何帮助那些需要希望的病人的,”现在已经退休的史密斯说。“这是我的家人的愿望,给医院的病人带来希望MD安德森”。
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