MD安德森的研究人员发现乐动体育LDsports中国,这些循环肿瘤细胞(CTCs)特别依赖于HER3蛋白在网膜(覆盖并支持腹部器官的脂肪组织鞘)上安家。
“这种关于卵巢癌转移的全新思考方式为预测和防止复发或扩散提供了新的潜在途径,”医学博士Anil Sood说妇科肿瘤与生殖医学和癌症生物学.
HER3,人类表皮生长因子受体3,是更著名的HER2的兄弟,活跃于20 - 25%的乳腺癌病例,是曲妥珠单抗或赫赛汀的靶点。HER3在卵巢ctc上的大量存在使其成为转移的潜在指标和治疗的新靶点。
Sood,该研究的资深作者,第一作者Sunila Pradeep博士,妇科肿瘤和生殖医学讲师,和他的同事们在《癌细胞》杂志上报告了他们的发现。
Anil Sood和他的研究团队发现乐动体育LDsports中国,某些卵巢癌细胞依赖于一种名为HER3的蛋白质来锁定大网膜,大网膜是一种覆盖并支撑腹部器官的脂肪组织鞘。细胞从那里扩散。
该团队使用小鼠模型实验表明,ctc扩散到大网膜,超过95%的细胞高度表达HER3。他们还发现,通过像锁上的钥匙一样插入HER3来激活HER3的蛋白质在大网膜转移中也大量存在。
这种被称为NRG1的激活蛋白被发现在大网膜内和周围比在邻近器官上更明显地表达。
“大网膜中表达的NRG1配体吸引her3阳性的ctc,”Sood说。
阻断HER3可能会增加存活率
在11例卵巢癌患者的肿瘤样本中,90%的细胞her3阳性。在5例大网膜血管中发现的肿瘤细胞也有很强的HER3表达。
在一项217名晚期患者的队列研究中,较低的HER3表达与提高近5年的总生存率相关,而高HER3肿瘤仅为3年多。乐动体育LDsports中国研究人员发现HER3在III期和IV期肿瘤中的表达明显高于I期和II期肿瘤。
Sood指出,该团队的发现可能导致使用her3阳性细胞作为患者复发或卵巢癌高危女性发生的生物标志物。治疗后维持抗her3治疗可预防或延缓复发。
目前正在开发阻断HER3的药物。它与HER2的相似性可能使它对击中这个目标的药物很脆弱。帕妥珠单抗(pertuzumab)的临床试验正在进行中,这是一种阻断HER2的抗体,旨在探索它是否可能抑制卵巢癌和乳腺癌中的两种蛋白质。
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/new-surgical-protocol-for-ovarian-cancer/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.sqjdzK8h9l.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/could-proton-therapy-be-holy-grail-for-head-and-neck-cancer/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.8I8ZnBLJVR.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/finding-solution-to-get-patients-back-on-their-feet/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.9RVMOntZms.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/early-stage-breast-cancer-less-aggressive-approach-can-be-effective/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic._gZ8-eM6-9.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/childhood-cancer-survivors-teenage-worries-college-and-boys/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.X9v1277AU6.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/tiny-clues-may-help-scientists-solve-its-mystery/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.AcP_L5mdke.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/grants-fuel-tomorrows-cancer-breakthroughs/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.F2Cx3TsRIt.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/industry-collaborations-boost-immune-systems-cancer-fighting-abilities/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.NuGBmIWEUI.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/developing-a-drug-to-starve-cancer-cells/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.Eqo-kKl9Cy.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/the-road-to-recovery-minus-the-traffic/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.MZuBHGxHi6.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/an-exchange-program-brings-the-best-to-brazil/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.iTRSX6XK7O.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/a-call-to-action-in-south-texas/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.x10AL6nRgv.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/the-physician-assistant-will-see-you-now/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.XhZT3yMOVC.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/the-angelic-side-of-austins-devilish-taco-king/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.Uf_Lrru81r.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/with-elevated-risks-these-survivors-and-previvors-arent-taking-a/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.VmmBVxLwbx.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/solving-baby-boomers-problem-with-hepatitis-c/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.oANmjfZVUg.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/outreach-delivers-screening-and-hope-to-communities-in-need/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.IJ9uoKhJki.jpg)
![](http://www.windowstask.com/content/mda/en/publications/annual-report/annual-report-2014/a-survivor-is-saving-lives-through-early-detection/_jcr_content/xfeaturedImage.resize.jpg.pagespeed.ic.u2y78tpJzE.jpg)