在实验室中确定有针对性的预防疗法,并将这些发现转移到临床中,这一直是维拉-桑切斯医学博士的研究重点临床癌症预防。
他的主要研究侧重于那些遗乐动体育LDsports中国传易受直肠癌的人。Vilar-Sanchez和Paul Scheet,Ph.D.,副教授流行病学,正在使用最新的基因组技术来研究大肠中的预align病变(息肉)。
“我们知道息肉是导致结肠癌发展的过程中的第一步,”Vilar-Sanchez说。
家族性腺瘤息肉(FAP)是一种遗传条件,其中在结肠和直肠中成千上万的息肉形式。如果没有治疗,息肉变得恶性。
“在一般人群中,在结肠镜检查期间检测到的绝大多数息肉是良性的或仍然在发展的前进的发展阶段,”Vilar-Sanchez说。“但我们仍然需要更好地了解将这些息肉转化为癌症的生物机制。这对FAP的人来说尤为重要,因为它们种了数百个息肉。因此,息肉成为癌症的机会非常高。“
随着种子资金邓肯家族癌症预防和风险评估研究所维拉-桑切斯和他的团队正在检查FAP患者的息肉,以制定预防策略并阻止它们的生长。
他的其他研究兴趣侧重乐动体育LDsports中国于林奇综合征 - 一种罕见的遗传条件,由负责修复DNA错误的基因中的种系突变引起。这项研究由乐动体育LDsports中国Feinberg家族礼物提供支持,是纽约艾伯特爱因斯坦医学院的合作研究。VILAR-SANCHEZ和他的团队正在使用转基因小鼠来识别和开发新的化学普化药物以靶向这种疾病。
他说:“我们需要确定哪种药物,或常用药物的组合,将最有效地阻止林奇综合征患者息肉的发展。”
但他的研究计划具乐动体育LDsports中国有更广泛的目标。VILAR-SANCHEZ表示,由于遗传条件,他的研究不仅会使他的学习使那些具有高患有结肠癌风险的人,但发现有可能帮助那些具有平均风险的人。
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