长期以来,人们认为CA-125蛋白可以预测卵巢癌对治疗和复发的反应,现在,它有望作为一种早期筛查工具。
“找到一种筛查机制将是对抗卵巢癌的圣杯,”医学博士Karen Lu说妇科肿瘤与生殖医学在MD安德森。“当早期抓到时,它不仅仅是可治疗的,它是可治愈的。”
由MD Anderson领导,一个11年的学习,全国注册了4,051名妇女。所有人都健康,绝经后,没有卵巢或乳腺癌的家族史。
女性接受了基线CA-125血液测试。使用基于年龄和CA-125分数的数学模型,研究参与者被置于三个风险群体中的一种:低,中间或高。医学随访相应相应。
根据CA-125随时间的变化,总共有117名研究参与者被确定为高危人群。她们接受了经阴道超声检查,然后转介给妇科肿瘤医生。其中有10名女性接受了手术。其中4人患有早期、侵袭性、高级别上皮性肿瘤,这些肿瘤是在最早、最可治愈的阶段被发现的。两位女性患有边缘性疾病,一位患有子宫内膜癌,三位患有良性卵巢肿瘤。
陆教授强调说,这些发现虽然令人鼓舞,但既不是决定性的,也不是改变实践的。英国正在进行一项大型随机前瞻性筛查试验,试验对象超过20万名女性。结果将在2015年揭晓。
“作为一名治疗患有这种疾病的女性超过十年的临床医生,我承认对卵巢癌筛查持怀疑态度,”卢说。“有了这些发现,我谨慎乐观地认为,在不久的将来,我们可能会提供一种筛查方法,可以在疾病的早期阶段发现疾病,并改变需要帮助的女性的生活。”
“找到一种筛查机制将是对抗卵巢癌的圣杯。如果发现得早,不仅可以治疗,而且是可以治愈的。”
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