“我们开发了一种能够识别高分子量蛋白质的抗体,这种蛋白质从大约80%的卵巢癌中脱落,”转化研究的副总裁解释说。乐动体育LDsports中国“它不是作为筛查试验设计的,而是为了跟踪已知卵巢癌患者,确定她们对治疗的反应,并检测复发。”
然而,这并没有阻止卵巢癌研究人员的研究。乐动体育LDsports中国自30多年前巴斯特的发现以来,许多人研究了CA-125在早期检测中的作用,但鲜有成功。
巴斯特和卡伦·卢,医学博士妇科肿瘤与生殖医学他认为一种更好的生物标志物,再加上新技术,最终将超过CA-125。然而,在面对面的科学研究中,没有发现更好的标记。这一发现,再加上CA-125随时间变化的数学模型,再次引起了人们的兴趣。
因此,MD安德森领导的CA-125研究诞生了。来自全国7个地点的4000多名健康妇女被招募,并收集了2万多份血液样本。迄今为止,除了一种以外,所有卵巢癌都是在早期、最可治愈的阶段被发现的。
这样的审判需要大量的资源。巴斯特说,尽管MD安德森拥有来自国家癌症研究所的大型卓越研究专项拨款,但慈善支持对该研究的成功至关重要。乐动体育LDsports中国
他坚持说:“没有“高尔夫抗癌协会”、“特雷西·乔·威尔逊卵巢癌基金会”、“苔藓基金会”、“诺顿家族”,特别是斯图尔特和盖伊·林恩·扎罗夫妇的年复一年的慷慨捐助,这种规模和范围的试验是不可能的。”
全国各地的每个筛查点也依赖于当地的捐赠者。
时间将很快告诉我们CA-125是否最终满足了早期卵巢癌筛查工具的需求——英国大型试验的结果将于2015年公布。
“32年后,如果CA-125能更早地检测到卵巢癌,我们都会很高兴,”巴斯特说。“但要继续前进,我们真的需要发现如何加快筛查测试的进一步发展。”
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