Renata Ferrarotto博士

Ferrarotto博士的工作主要集中在检测肺癌和头颈部肿瘤样本的基因和蛋白质表达谱，以确定可以用合适的治疗方案有针对性的改变。To accomplish this, alterations of genes and proteins found in tumor samples are correlated with the patient’s individual tumor characteristics and clinical outcomes (disease progression and survival), then the effects of different drugs targeting the gene or protein of interest are examined in cell line and mouse models, and finally the results obtained in the lab are used to develop and design clinical trials with new therapeutic regimens for patients. Currently, Dr. Ferrarotto is leading a project to investigate the importance of Notch1 mutations in patients diagnosed with adenoid cystic carcinoma (ACC), a rare salivary gland tumor. Her work demonstrated that Notch1 mutations in ACC define a subgroup of patients with an aggressive disease and propensity to liver and bone metastasis.

Ferrarotto博士是一位肿瘤科医生致力于提高从胸部和头颈部恶性肿瘤患者的生活质量和长度。她致力时间照顾病人，以及临床和转化研究。乐动体育LDsports中国Dr. Ferrarotto’s work focuses on identifying predictive biomarkers that can be used to select the patients that will benefit the most from targeted therapy and immunotherapy, particularly in the area of rare cancers (salivary gland cancer, small cell lung cancer, skin cancers, sinonasal cancers, anaplastic thyroid cancer ) that represent a major unmet need. Currently, she directs three clinical trials with targeted therapy and four clinical trials with immunotherapy. In addition, Dr. Ferrarotto is also actively involved in the treatment of oropharyngeal cancers associated with human papillomavirus (HPV) using targeted therapy, immunotherapy, treatment de-intensification and pre-operative systemic therapy.

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